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Listar por autor "Pérez Calero, Carmen"
Mostrando ítems 1-7 de 7
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Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
Sessa, Gaetana; Gómez González, Belén María; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
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Artículo
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
Salas Armenteros, Irene; Pérez Calero, Carmen; Bayona Feliu, Aleix; Tumini, Emanuela; Luna Varo, Rosa María; Aguilera López, Andrés (Wiley-Blackwell, 2017)R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Tesis Doctoral
Papel de la helicasa UAP56/DDX39B y otros factores asociados al metabolismo del ARN en la integridad del genoma
Pérez Calero, Carmen (2020-02-12)Para la transmisión fidedigna de la información genética es indispensable preservar la integridad del genoma. Las células ...
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Artículo
Roles of human POLD1 and POLD3 in genome stability
Tumini, Emanuela; Barroso Ceballos, Sonia Inés; Pérez Calero, Carmen; Aguilera López, Andrés (Nature, 2016)DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
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Artículo
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015)Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
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Artículo
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020)Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...